Pulmonary Hypertension

Pulmonary Hypertension is a topic covered in the Harrison's Manual of Medicine.

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Definition

Elevation of pulmonary artery (PA) pressure due to pulmonary vascular or parenchymal disease, increased left heart filling pressures, or a combination. Table 127-1 lists etiologies by categories.

TABLE 127-1: CLASSIFICATION OF PULMONARY HYPERTENSION
  1. Pulmonary Arterial Hypertension
    • Idiopathic
    • Heritable (mutations/familial cases)
    • Collagen vascular diseases (e.g., scleroderma, SLE, RA)
    • Congenital systemic to pulmonary shunts (e.g., ventricular septal defect, patent ductus arteriosus, atrial septal defect)
    • Portal hypertension
    • HIV infection
    • Drugs or toxins (e.g., fenfluramine)
  2. Pulmonary Hypertension Due to Left Heart Disease
    • LV systolic or diastolic dysfunction
    • Left-sided valvular disease
  3. Pulmonary Hypertension Due to Lung Disease or Hypoxia
    • Chronic obstructive lung disease
    • Interstitial lung disease
    • Sleep-disordered breathing
    • Chronic hypoventilation
  4. Chronic Pulmonary Thromboembolic Disease
    • Chronic pulmonary embolism
  5. Miscellaneous
    • Systemic conditions (e.g., sarcoidosis, pulmonary histiocytosis)
    • Hematologic conditions (e.g., myeloproliferative diseases)
Abbreviations: RA, rheumatoid arthritis.

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Citation

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TY - ELEC T1 - Pulmonary Hypertension ID - 623042 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623042/all/Pulmonary_Hypertension ER -