Sepsis and Septic Shock

Sepsis and Septic Shock is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or purchase a subscription.

Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

Harrison’s Manual of Medicine - App + Web

-- The first section of this topic is shown below --


  • Possibly harmful systemic response: Two or more of the following:
    • Fever (oral temperature >38°C [100.4°F]) or hypothermia (oral temperature <36°C [96.8°F])
    • Tachypnea (>24 breaths/min)
    • Tachycardia (>90 beats/min)
    • Leukocytosis (>12,000/μL), leukopenia (<4000/μL), or >10% bands; may have a noninfectious etiology
  • Sepsis (or severe sepsis): Harmful systemic response (including some degree of organ hypofunction) with a proven or suspected microbial etiology
  • Septic shock: Sepsis with hypotension (arterial bp <90 mmHg or 40 mmHg below pt’s normal bp for at least 1 h despite fluid resuscitation) or need for vasopressors to maintain systolic bp ≥90 mmHg or mean arterial bp ≥70 mmHg

-- To view the remaining sections of this topic, please or purchase a subscription --