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Sepsis and Septic Shock

Sepsis and Septic Shock is a topic covered in the Harrison's Manual of Medicine.

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  • Possibly harmful systemic response: Two or more of the following:
    • Fever (oral temperature >38°C [100.4°F]) or hypothermia (oral temperature <36°C [96.8°F])
    • Tachypnea (>24 breaths/min)
    • Tachycardia (>90 beats/min)
    • Leukocytosis (>12,000/μL), leukopenia (<4000/μL), or >10% bands; may have a noninfectious etiology
  • Sepsis (or severe sepsis): Harmful systemic response (including some degree of organ hypofunction) with a proven or suspected microbial etiology
  • Septic shock: Sepsis with hypotension (arterial bp <90 mmHg or 40 mmHg below pt’s normal bp for at least 1 h despite fluid resuscitation) or need for vasopressors to maintain systolic bp ≥90 mmHg or mean arterial bp ≥70 mmHg

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Loscalzo, Joseph, et al., editors. "Sepsis and Septic Shock." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623035/all/Sepsis_and_Septic_Shock.
Sepsis and Septic Shock. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623035/all/Sepsis_and_Septic_Shock. Accessed April 23, 2019.
Sepsis and Septic Shock. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623035/all/Sepsis_and_Septic_Shock
Sepsis and Septic Shock [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623035/all/Sepsis_and_Septic_Shock.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Sepsis and Septic Shock ID - 623035 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623035/all/Sepsis_and_Septic_Shock PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -