Chapter 14: Sepsis and Septic Shock

Chapter 14: Sepsis and Septic Shock is a topic covered in the Harrison's Manual of Medicine.

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  • Sepsis: a life-threatening organ dysfunction caused by a dysregulated host response to infection.
  • Septic shock: a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities lead to substantially increased mortality risk. Pts need vasopressor therapy to elevate mean arterial pressure to ≥65 mmHg with a serum lactate concentration >2.0 mmol/L despite adequate fluid resuscitation.

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