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HEPATOCELLULAR CARCINOMA

About 28,720 cases in the United States in 2012, but worldwide this may be the most common tumor; 20,550 deaths in 2012 in US. Male:female = 4:1; tumor usually develops in cirrhotic liver in persons in fifth or sixth decade. High incidence in Asia and Africa is related to etiologic relationship between this cancer and hepatitis B and C infections. Aflatoxin exposure contributes to etiology and leaves a molecular signature, a mutation in codon 249 of the gene for p53.


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