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PRINCIPLES OF MANAGEMENT

PRINCIPLES OF MANAGEMENT is a topic covered in the Harrison's Manual of Medicine.

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If a causative agent can be identified (e.g., thermophilic actinomyces in hypersensitivity pneumonitis), cessation of exposure to that agent is imperative. Because the response to treatment among different ILDs is so variable, identification of treatable causes is essential. Glucocorticoids can be highly effective for eosinophilic pneumonias, COP, hypersensitivity pneumonitis (HP), acute radiation pneumonitis, and drug-induced ILD. Prednisone at 0.5–1.0 mg/kg per day is commonly given for 4–12 weeks, followed by a gradual tapering dose. On the other hand, glucocorticoids are usually not beneficial in IPF. Smoking cessation is essential, especially for smoking-related ILDs such as PLCH and respiratory bronchiolitis.

Supportive therapeutic measures include providing supplemental O2 for pts with significant hypoxemia (PaO2 <55 mmHg at rest and/or with exercise). Pulmonary rehabilitation is often beneficial. For younger pts with end-stage ILD, lung transplantation should be considered.

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Citation

Loscalzo, Joseph, et al., editors. "PRINCIPLES of MANAGEMENT." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623694/all/PRINCIPLES_OF_MANAGEMENT.
PRINCIPLES OF MANAGEMENT. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623694/all/PRINCIPLES_OF_MANAGEMENT. Accessed April 23, 2019.
PRINCIPLES OF MANAGEMENT. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623694/all/PRINCIPLES_OF_MANAGEMENT
PRINCIPLES of MANAGEMENT [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623694/all/PRINCIPLES_OF_MANAGEMENT.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - PRINCIPLES OF MANAGEMENT ID - 623694 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623694/all/PRINCIPLES_OF_MANAGEMENT PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -