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Alcohol Use Disorder

Alcohol Use Disorder is a topic covered in the Harrison's Manual of Medicine.

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Alcohol use disorder is defined as repeated alcohol-related difficulties in at least 2 of 11 life areas that cluster together in the same 12-month period (Table 199-1). Severity is based on the number of items endorsed: mild is two or three items, moderate is four or five, and severe is six or more.


Two or more of the following items occurring in the same 12-month period must be endorsed for the diagnosis of an AUDa:

 Drinking resulting in recurrent failure to fulfill role obligations

 Recurrent drinking in hazardous situations

 Continued drinking despite alcohol-related social or interpersonal problems


 Withdrawal, or substance use for relief/avoidance of withdrawal

 Drinking in larger amounts or for longer than intended

 Persistent desire/unsuccessful attempts to stop or reduce drinking

 Great deal of time spent obtaining, using, or recovering from alcohol

 Important activities given up/reduced because of drinking

 Continued drinking despite knowledge of physical or psychological problems caused by alcohol

 Alcohol craving

aMild AUD: 2–3 criteria required; moderate AUD: 4–5 items endorsed; severe AUD: 6 or more items endorsed.

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Loscalzo, Joseph, et al., editors. "Alcohol Use Disorder." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623691/all/Alcohol_Use_Disorder.
Alcohol Use Disorder. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623691/all/Alcohol_Use_Disorder. Accessed April 23, 2019.
Alcohol Use Disorder. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623691/all/Alcohol_Use_Disorder
Alcohol Use Disorder [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623691/all/Alcohol_Use_Disorder.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Alcohol Use Disorder ID - 623691 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623691/all/Alcohol_Use_Disorder PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -