SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)

SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) is a topic covered in the Harrison's Manual of Medicine.

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DEFINITION AND PATHOGENESIS

Disease of unknown etiology in which tissues and cells undergo damage mediated by tissue-binding autoantibodies and immune complexes. Genetic, environmental, and sex hormonal factors are likely of pathogenic importance. T- and B-cell hyperactivity, production of autoantibodies with specificity for nuclear antigenic determinants, and abnormalities of T-cell function occur.

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Citation

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TY - ELEC T1 - SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) ID - 623669 ED - Fauci,Anthony S, ED - Hauser,Stephen L, ED - Jameson,J Larry, ED - Kasper,Dennis L, ED - Longo,Dan L, ED - Loscalzo,Joseph, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623669/all/SYSTEMIC_LUPUS_ERYTHEMATOSUS__SLE_ PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -