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THE NEUROLOGIC METHOD AND LOCALIZATION is a topic covered in the Harrison's Manual of Medicine.

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The clinical data obtained from the neurologic examination coupled with a careful history are interpreted to arrive at an anatomic localization that best explains the clinical findings (Table 180-2), to narrow the list of diagnostic possibilities, and to select the diagnostic tests most likely to be informative.

CerebrumAbnormal mental status or cognitive impairment
 Unilateral weaknessa and sensory abnormalities including head and limbs
 Visual field abnormalities
 Movement abnormalities (e.g., diffuse incoordination, tremor, chorea)
BrainstemIsolated cranial nerve abnormalities (single or multiple)
 “Crossed” weaknessa and sensory abnormalities of head and limbs, e.g., weakness of right face and left arm and leg
Spinal cordBack pain or tenderness
 Weaknessa and sensory abnormalities sparing the head
 Mixed upper and lower motor neuron findings
 Sensory level
 Sphincter dysfunction
Spinal rootsRadiating limb pain
 Weaknessb or sensory abnormalities following root distribution (see Figs. 180-1 and 180-2)
 Loss of reflexes
Peripheral nerveMid or distal limb pain
 Weaknessb or sensory abnormalities following nerve distribution (see Figs. 180-1 and 180-2)
 “Stocking or glove” distribution of sensory loss
 Loss of reflexes
Neuromuscular junctionBilateral weakness including face (ptosis, diplopia, dysphagia) and proximal limbs
 Increasing weakness with exertion
 Sparing of sensation
MuscleBilateral proximal or distal weakness
 Sparing of sensation
aWeakness along with other abnormalities having an “upper motor neuron” pattern, i.e., spasticity, weakness of extensors > flexors in the upper extremity and flexors > extensors in the lower extremity, and hyperreflexia.
bWeakness along with other abnormalities having a “lower motor neuron” pattern, i.e., flaccidity and hyporeflexia.

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Loscalzo, Joseph, et al., editors. "THE NEUROLOGIC METHOD and LOCALIZATION." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623457/all/THE_NEUROLOGIC_METHOD_AND_LOCALIZATION.
THE NEUROLOGIC METHOD AND LOCALIZATION. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623457/all/THE_NEUROLOGIC_METHOD_AND_LOCALIZATION. Accessed April 23, 2019.
THE NEUROLOGIC METHOD AND LOCALIZATION. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623457/all/THE_NEUROLOGIC_METHOD_AND_LOCALIZATION
THE NEUROLOGIC METHOD and LOCALIZATION [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623457/all/THE_NEUROLOGIC_METHOD_AND_LOCALIZATION.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - THE NEUROLOGIC METHOD AND LOCALIZATION ID - 623457 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623457/all/THE_NEUROLOGIC_METHOD_AND_LOCALIZATION PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -