CALCIUM APATITE DEPOSITION DISEASE

CALCIUM APATITE DEPOSITION DISEASE is a topic covered in the Harrison's Manual of Medicine.

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Apatite is the primary mineral of normal bone and teeth. Abnormal accumulation can occur in a wide range of clinical settings (Table 164-2). Apatite is an important factor in Milwaukee shoulder, a destructive arthropathy of the elderly that occurs in the shoulders and knees. Apatite crystals are small; clumps may stain purplish on Wright's stain and bright red with alizarin red S. Definitive identification requires electron microscopy or x-ray diffraction studies. Radiographic appearance resembles CPPD disease. Treatment: NSAIDs, repeated aspiration, and rest of affected joint.

TABLE 164-2: CONDITIONS ASSOCIATED WITH APATITE DEPOSITION DISEASE
Aging
Osteoarthritis
Hemorrhagic shoulder effusions in the elderly (Milwaukee shoulder)
Destructive arthropathy
Tendinitis, bursitis
Tumoral calcinosis (sporadic cases)

Disease-associated

 Hyperparathyroidism

 Milk-alkali syndrome

 Renal failure/long-term dialysis

 Connective tissue diseases (e.g., systemic sclerosis, idiopathic myositis, SLE)

 Heterotopic calcification following neurologic catastrophes (e.g., stroke, spinal cord injury)

Heredity
Bursitis, arthritis
Tumoral calcinosis
Fibrodysplasia ossificans progressiva

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TY - ELEC T1 - CALCIUM APATITE DEPOSITION DISEASE ID - 623401 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE ER -