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CALCIUM APATITE DEPOSITION DISEASE is a topic covered in the Harrison's Manual of Medicine.

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Apatite is the primary mineral of normal bone and teeth. Abnormal accumulation can occur in a wide range of clinical settings (Table 164-2). Apatite is an important factor in Milwaukee shoulder, a destructive arthropathy of the elderly that occurs in the shoulders and knees. Apatite crystals are small; clumps may stain purplish on Wright's stain and bright red with alizarin red S. Definitive identification requires electron microscopy or x-ray diffraction studies. Radiographic appearance resembles CPPD disease. Treatment: NSAIDs, repeated aspiration, and rest of affected joint.

Hemorrhagic shoulder effusions in the elderly (Milwaukee shoulder)
Destructive arthropathy
Tendinitis, bursitis
Tumoral calcinosis (sporadic cases)



 Milk-alkali syndrome

 Renal failure/long-term dialysis

 Connective tissue diseases (e.g., systemic sclerosis, idiopathic myositis, SLE)

 Heterotopic calcification following neurologic catastrophes (e.g., stroke, spinal cord injury)

Bursitis, arthritis
Tumoral calcinosis
Fibrodysplasia ossificans progressiva

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Loscalzo, Joseph, et al., editors. "CALCIUM APATITE DEPOSITION DISEASE." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE.
CALCIUM APATITE DEPOSITION DISEASE. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE. Accessed April 23, 2019.
CALCIUM APATITE DEPOSITION DISEASE. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE
CALCIUM APATITE DEPOSITION DISEASE [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 23]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - CALCIUM APATITE DEPOSITION DISEASE ID - 623401 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623401/all/CALCIUM_APATITE_DEPOSITION_DISEASE PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -