CALCIUM PYROPHOSPHATE DIHYDRATE (CPPD) DEPOSITION DISEASE (PSEUDOGOUT)

CALCIUM PYROPHOSPHATE DIHYDRATE (CPPD) DEPOSITION DISEASE (PSEUDOGOUT) is a topic covered in the Harrison's Manual of Medicine.

To view the entire topic, please or purchase a subscription.

Harrison’s Manual of Medicine 19th edition provides 600+ internal medicine topics in a rapid-access format. Download Harrison’s App to iPhone, iPad, and Android smartphone and tablet. Explore these free sample topics:

Harrison’s Manual of Medicine - App + Web

-- The first section of this topic is shown below --

DEFINITION AND PATHOGENESIS

CPPD disease is characterized by acute and chronic inflammatory joint disease, usually affecting older individuals. The knee and other large joints are most commonly affected. Calcium deposits in articular cartilage (chondrocalcinosis) may be seen radiographically; these are not always associated with symptoms.

CPPD is most often idiopathic but can be associated with other conditions (Table 164-1).

TABLE 164-1: CONDITIONS ASSOCIATED WITH CPPD DEPOSITION DISEASE
Aging
Disease-associated

 Primary hyperparathyroidism

 Hemochromatosis

 Hypophosphatasia

 Hypomagnesemia

 Chronic gout

 Postmeniscectomy

 Gitelman’s syndrome

Epiphyseal dysplasias

Crystals are thought not to form in synovial fluid but are probably shed from articular cartilage into joint space, where they are phagocytosed by neutrophils and incite an inflammatory response.

-- To view the remaining sections of this topic, please or purchase a subscription --

Citation

* When formatting your citation, note that all book, journal, and database titles should be italicized* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - CALCIUM PYROPHOSPHATE DIHYDRATE (CPPD) DEPOSITION DISEASE (PSEUDOGOUT) ID - 623400 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623400/all/CALCIUM_PYROPHOSPHATE_DIHYDRATE__CPPD__DEPOSITION_DISEASE__PSEUDOGOUT_ ER -