Harrison's Manual of Medicine
MUCORMYCOSIS
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MICROBIOLOGY AND EPIDEMIOLOGY
Mucormycosis is caused by fungi of the order Mucorales, most commonly Rhizopus oryzae and R. delemar; despite the name of the disease, Mucor species are only rarely the cause.
- Mucorales have characteristic wide (≥6- to 30-µm), thick-walled, ribbon-like, aseptate hyphal elements that branch at right angles.
- These ubiquitous environmental fungi primarily affect pts with diabetes, solid organ or hematopoietic stem cell transplants, prolonged neutropenia, malignancy, and deferoxamine treatment for iron overload syndromes.
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MICROBIOLOGY AND EPIDEMIOLOGY
Mucormycosis is caused by fungi of the order Mucorales, most commonly Rhizopus oryzae and R. delemar; despite the name of the disease, Mucor species are only rarely the cause.
- Mucorales have characteristic wide (≥6- to 30-µm), thick-walled, ribbon-like, aseptate hyphal elements that branch at right angles.
- These ubiquitous environmental fungi primarily affect pts with diabetes, solid organ or hematopoietic stem cell transplants, prolonged neutropenia, malignancy, and deferoxamine treatment for iron overload syndromes.
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