ASPERGILLOSIS
MICROBIOLOGY AND EPIDEMIOLOGY
Aspergillus, a mold with septate hyphae branching at 45° angles, has vast numbers of conidia (spores). It has a worldwide distribution and typically grows in decomposing plant materials and in bedding. A. fumigatus is responsible for most cases of invasive aspergillosis, almost all cases of chronic aspergillosis, and most allergic syndromes.
- Inhalation is common; only intense exposures cause disease in healthy, immunocompetent individuals.
- The primary risk factors for invasive aspergillosis are profound neutropenia, glucocorticoid use, therapy with immune modulators (e.g., TNF-α inhibitors, ibrutinib), severe liver disease, influenza infection, and extracorporeal membrane oxygenation therapy.
- Pts with chronic pulmonary aspergillosis have a wide spectrum of underlying pulmonary diseases (e.g., tuberculosis, sarcoidosis).
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Citation
Kasper, Dennis L., et al., editors. "ASPERGILLOSIS." Harrison's Manual of Medicine, 20th ed., McGraw Hill Inc., 2020. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623284/0/ASPERGILLOSIS.
ASPERGILLOSIS. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623284/0/ASPERGILLOSIS. Accessed December 9, 2024.
ASPERGILLOSIS. (2020). In Kasper, D. L., Fauci, A. S., Hauser, S. L., Longo, D. L., Jameson, J. L., & Loscalzo, J. (Eds.), Harrison's Manual of Medicine (20th ed.). McGraw Hill Inc.. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623284/0/ASPERGILLOSIS
ASPERGILLOSIS [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, Jameson JLJ, Loscalzo JJ, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2020. [cited 2024 December 09]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623284/0/ASPERGILLOSIS.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - ASPERGILLOSIS
ID - 623284
ED - Jameson,J Larry,
ED - Loscalzo,Joseph,
ED - Kasper,Dennis L,
ED - Fauci,Anthony S,
ED - Hauser,Stephen L,
ED - Longo,Dan L,
BT - Harrison's Manual of Medicine
UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623284/0/ASPERGILLOSIS
PB - McGraw Hill Inc.
ET - 20
DB - Harrison's Manual of Medicine
DP - Unbound Medicine
ER -