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TULAREMIA

TULAREMIA is a topic covered in the Harrison's Manual of Medicine.

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Microbiology and Epidemiology

Tularemia is the only disease caused by Francisella tularensis, a small, gram-negative, aerobic bacillus that is a potential agent of bioterrorism.

  • Human infection occurs via interaction with biting or blood-sucking insects (especially ticks and tabanid flies in the spring and summer), wild or domestic animals (e.g., wild rabbits, squirrels), or the environment.
    • The organism gains entry into the skin or mucous membranes through bites or inapparent abrasions or is acquired via inhalation or ingestion.
    • As few as 10 organisms can result in infection when injected into the skin or inhaled; >108 organisms are required to produce infection via the oral route.
  • More than half of U.S. cases occur in Arkansas, Oklahoma, and Missouri.

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Citation

Loscalzo, Joseph, et al., editors. "TULAREMIA." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623237/all/TULAREMIA.
TULAREMIA. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623237/all/TULAREMIA. Accessed April 21, 2019.
TULAREMIA. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623237/all/TULAREMIA
TULAREMIA [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 21]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623237/all/TULAREMIA.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - TULAREMIA ID - 623237 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623237/all/TULAREMIA PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -