Weight Loss is a topic covered in the Harrison's Manual of Medicine.

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Significant unintentional weight loss in a previously healthy individual is often a harbinger of underlying systemic disease. The routine medical history should always include inquiry about changes in weight. Rapid fluctuations of weight over days suggest loss or gain of fluid, whereas long-term changes usually involve loss of tissue mass. Loss of 5% of body weight over 6–12 months should prompt further evaluation. Gradual weight loss is physiologic in persons over age 80, but this demographic group also has a high risk for malignancy or other serious illness.

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Citation

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TY - ELEC T1 - Weight Loss ID - 623166 Y1 - 2017 PB - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623166/all/Weight_Loss ER -