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Fever, Hyperthermia, and Rash

Fever, Hyperthermia, and Rash is a topic covered in the Harrison's Manual of Medicine.

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DEFINITIONS

  • Temperature: The hypothalamic thermoregulatory center balances excess heat production from metabolic activity in muscle and liver with heat dissipation from the skin and lungs to maintain a normal body temperature of 36.8° ± 0.4°C (98.2° ± 0.7°F), with diurnal variation (lower in a.m., higher in p.m.).
  • Fever: an elevation of body temperature (>37.2°C/98.9°F in the morning and >37.7°C/99.9°F in the evening) in conjunction with an increase in the hypothalamic set point
  • Fever of unknown origin (FUO): temperatures >38.3°C (>101°F) on two or more occasions and an illness duration of ≥3 weeks, with no known immunocompromised state and unrevealing laboratory and radiologic investigations into the cause
  • Hyperpyrexia: temperatures >41.5°C (>106.7°F) that can occur with severe infections but more commonly occur with CNS hemorrhages
  • Hyperthermia: an uncontrolled increase in body temperature that exceeds the body’s ability to lose heat without a change in the hypothalamic set point. Hyperthermia does not involve pyrogenic molecules.
  • Pyrogen: any fever-causing substance, including exogenous pyrogens (e.g., microbial toxins, lipopolysaccharide, superantigens) and pyrogenic cytokines (e.g., IL-1, IL-6, TNF)

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Citation

Loscalzo, Joseph, et al., editors. "Fever, Hyperthermia, and Rash." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623164/all/Fever__Hyperthermia__and_Rash.
Fever, Hyperthermia, and Rash. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623164/all/Fever__Hyperthermia__and_Rash. Accessed April 21, 2019.
Fever, Hyperthermia, and Rash. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623164/all/Fever__Hyperthermia__and_Rash
Fever, Hyperthermia, and Rash [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 21]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623164/all/Fever__Hyperthermia__and_Rash.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Fever, Hyperthermia, and Rash ID - 623164 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623164/all/Fever__Hyperthermia__and_Rash PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -