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Adverse Drug Reactions

Adverse Drug Reactions is a topic covered in the Harrison's Manual of Medicine.

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Adverse drug reactions are among the most frequent problems encountered clinically and represent a common cause for hospitalization. They occur most frequently in pts receiving multiple drugs and are caused by:

  • Errors in self-administration of prescribed drugs (quite common in the elderly);
  • Exaggeration of intended pharmacologic effect (e.g., hypotension in a pt given antihypertensive drugs);
  • Concomitant administration of drugs with synergistic effects (e.g., aspirin and warfarin);
  • Cytotoxic reactions (e.g., hepatic necrosis due to acetaminophen);
  • Immunologic mechanisms (e.g., quinidine-induced thrombocytopenia, hydralazine-induced SLE);
  • Genetically determined enzymatic defects (e.g., primaquine-induced hemolytic anemia in G6PD deficiency); or
  • Idiosyncratic reactions (e.g., chloramphenicol-induced aplastic anemia).

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Citation

Loscalzo, Joseph, et al., editors. "Adverse Drug Reactions." Harrison's Manual of Medicine, 19th ed., McGraw Hill Inc., 2017. harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623134/all/Adverse_Drug_Reactions.
Adverse Drug Reactions. In: Loscalzo J, Jameson JL, Longo DL, et al, eds. Harrison's Manual of Medicine. 19th ed. McGraw Hill Inc.; 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623134/all/Adverse_Drug_Reactions. Accessed April 18, 2019.
Adverse Drug Reactions. (2017). In Loscalzo, J., Jameson, J. L., Longo, D. L., Hauser, S. L., Fauci, A. S., & Kasper, D. L. (Eds.), Harrison's Manual of Medicine. Available from https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623134/all/Adverse_Drug_Reactions
Adverse Drug Reactions [Internet]. In: Loscalzo J, Jameson JL, Longo DL, Hauser SL, Fauci AS, Kasper DL, editors. Harrison's Manual of Medicine. McGraw Hill Inc.; 2017. [cited 2019 April 18]. Available from: https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623134/all/Adverse_Drug_Reactions.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC T1 - Adverse Drug Reactions ID - 623134 ED - Loscalzo,Joseph, ED - Jameson,J Larry, ED - Longo,Dan L, ED - Hauser,Stephen L, ED - Fauci,Anthony S, ED - Kasper,Dennis L, BT - Harrison's Manual of Medicine UR - https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623134/all/Adverse_Drug_Reactions PB - McGraw Hill Inc. ET - 19 DB - Harrison's Manual of Medicine DP - Unbound Medicine ER -