Amyloidosis

Amyloidosis is a topic covered in the Harrison's Manual of Medicine.

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DEFINITION

Amyloidosis is a term for a group of protein folding disorders characterized by the extracellular deposition of insoluble polymeric protein fibrils in organs and tissues. Clinical manifestations depend on anatomic distribution and intensity of amyloid protein deposition; they range from local deposition with little significance to involvement of virtually any organ system with severe pathophysiologic consequences.

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