SYSTEMIC SCLEROSIS (SCLERODERMA, SSc)

DEFINITION AND PATHOGENESIS

SSc is a multisystem disorder characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs (chiefly GI tract, lungs, heart, and kidney). Pathogenesis unclear; involves immunologic mechanisms leading to vascular endothelial damage and activation of fibroblasts.

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