LIVER TRANSPLANTATION

Consider in the absence of contraindications for chronic, irreversible, progressive liver disease or fulminant hepatic failure when no alternative therapy is available (Table 157-4).

TABLE 157-4: Indications for Liver Transplantation
CHILDREN	ADULTS
Biliary atresia	Primary biliary cirrhosis
Neonatal hepatitis	Secondary biliary cirrhosis
Congenital hepatic fibrosis	Primary sclerosing cholangitis
Alagille’s syndrome^a	Autoimmune hepatitis
Byler’s disease^b	Caroli’s disease^c
α₁-Antitrypsin deficiency	Cryptogenic cirrhosis
Inherited disorders of metabolism	Chronic hepatitis with cirrhosis
Wilson’s disease	Hepatic vein thrombosis
Tyrosinemia	Fulminant hepatitis
Glycogen storage diseases	Alcoholic cirrhosis
Lysosomal storage diseases	Chronic viral hepatitis
Protoporphyria	Primary hepatocellular malignancies
Crigler-Najjar disease type I	Hepatic adenomas
Familial hypercholesterolemia	Nonalcoholic steatohepatitis
Primary hyperoxaluria type I	Familial amyloid polyneuropathy
Hemophilia

_aArteriohepatic dysplasia, with paucity of bile ducts, and congenital malformations, including pulmonary stenosis.

_bIntrahepatic cholestasis, progressive liver failure, and mental and growth retardation.

_cMultiple cystic dilatations of the intrahepatic biliary tree.

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