ANTIFUNGAL AGENTS

AMPHOTERICIN B (AmB)

AmB is the broadest-spectrum antifungal agent but has significant toxicities, including nephrotoxicity, fever, chills, and nausea.

AmB has fungicidal activity and is available only for parenteral administration.
Lipid formulations lack nephrotoxicity and infusion reactions; whether there is a clinically significant difference in efficacy between the deoxycholate and lipid formulations remains controversial.

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