Harrison's Manual of Medicine 17/e

Acne

Acne Vulgaris

Usually a self-limited disorder of teenagers and young adults. Comedones (small cyst formed in hair follicle) are clinical hallmark; often accompanied by inflammatory lesions of papules, pustules, or nodules. May scar in severe cases.

TREATMENT
Careful cleaning and removal of oils; oral tetracycline or erythromycin; topical antibacterials (e.g., benzoyl peroxide), topical retinoic acid. Systemic isotretinoin only for unresponsive severe nodulocystic acne (risk of severe adverse events including teratogenicity and possible association with depression).

Acne Rosacea

Inflammatory disorder affecting predominantly the central face, rarely affecting pts <30 years of age. Tendency toward exaggerated flushing, with eventual superimposition of papules, pustules, and telangiectases. May lead to rhinophyma and ocular problems.

TREATMENT
Oral tetracycline, 250-1000 mg/d; topical metronidazole and topical nonfluorinated glucocorticoids may be useful.

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