Harrison's Manual of Medicine 17/e
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Table 87-5: Antibiotic Regimens for Prophylaxis of Endocarditis in Adults with High-Risk Cardiac Lesions*

Table 87-5

Standard oral regimen

  1. Amoxicillin 2.0 g PO 1 h before procedure
Inability to take oral medication
  1. Ampicillin 2.0 g IV or IM within 1 h before procedure
Penicillin allergy
  1. Clarithromycin or azithromycin 500 mg PO 1 h before procedure
  2. Cephalexinc 2.0 g PO 1 h before procedure
  3. Clindamycin 600 mg PO 1 h before procedure
Penicillin allergy, inability to take oral medication
  1. Cefazolinc or ceftriaxone 1.0 g IV or IM 30 min before procedure
  2. Clindamycin 600 mg IV or IM 1h before procedure

*Dosing for children: For amoxicillin, ampicillin, cephalexin, or cefadroxil, use 50 mg/kg PO; cefazolin, 25 mg/kg IV; clindamycin, 20 mg/kg PO, 25 mg/kg IV; clarithromycin, 15 mg/kg PO; and vancomycin, 20 mg/kg IV.

†For high-risk lesions, see Table 87-4. Prophylaxis is not advised for other lesions.

cDo not use cephalosporins in pts with immediate hypersensitivity (urticaria, angioedema, anaphylaxis) to penicillin.

Source: W Wilson et al: Circulation, 116:1736, 2007.


Chapter:
Infective Endocarditis

Table 87-5: Antibiotic Regimens for Prophylaxis of Endocarditis in Adults with High-Risk Cardiac Lesions* has been found in Harrison's Manual of Medicine 17/e

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Table 87-5: Antibiotic Regimens for Prophylaxis of Endocarditis in Adults with High-Risk Cardiac Lesions*
Table 87-5
Last updated: May 11, 2009
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